Raymond L Benza Selected Research

Therapeutics

12/2023	Do Patients With Low-Risk Pulmonary Arterial Hypertension Really Benefit From Upfront Combination Therapy?: Insight From the AMBITION Trial.
7/2022	INSPIRE: Safety and tolerability of inhaled Yutrepia (treprostinil) in pulmonary arterial hypertension (PAH).
1/2022	Aggressive Afterload Lowering to Improve the Right Ventricle: A New Target for Medical Therapy in Pulmonary Arterial Hypertension?
1/2022	Two polymorphic gene loci associated with treprostinil dose in pulmonary arterial hypertension.
11/2021	Results From the United States Chronic Thromboembolic Pulmonary Hypertension Registry: Enrollment Characteristics and 1-Year Follow-up.
1/2021	Switching to riociguat versus maintenance therapy with phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension (REPLACE): a multicentre, open-label, randomised controlled trial.
1/2021	Enrichment Benefits of Risk Algorithms for Pulmonary Arterial Hypertension Clinical Trials.
10/2020	Pulmonary vasodilators: beyond the bounds of pulmonary arterial hypertension therapy in COVID-19.
10/2020	Safety and efficacy of transitioning from the combination of bosentan and sildenafil to alternative therapy in patients with pulmonary arterial hypertension.
11/2019	Bloodstream Infections in Continuous Flow Left Ventricular Assist Device Recipients: Diagnostic and Clinical Implications.

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Raymond L Benza Research Topics

Disease

60	Pulmonary Arterial Hypertension 03/2024 - 12/2005
25	Pulmonary Hypertension 01/2024 - 12/2005
15	Heart Failure 01/2023 - 09/2002
6	Hypertension (High Blood Pressure) 06/2022 - 07/2008
5	Connective Tissue Diseases (Connective Tissue Disease) 07/2017 - 03/2006
4	Cardiovascular Diseases (Cardiovascular Disease) 01/2023 - 05/2014
4	Disease Progression 11/2021 - 07/2014
4	Heart Diseases (Heart Disease) 01/2021 - 01/2002
3	Vascular Remodeling 01/2024 - 05/2007
3	Neoplasms (Cancer) 11/2021 - 12/2005
3	Hypotension (Low Blood Pressure) 01/2021 - 02/2015
3	Headache (Headaches) 01/2021 - 12/2011
3	Cardiac Arrhythmias (Arrythmia) 11/2020 - 05/2009
3	Sepsis (Septicemia) 11/2019 - 05/2002
3	Infections 10/2019 - 05/2002
3	Thrombosis (Thrombus) 10/2019 - 05/2014
3	Cardiomyopathies (Cardiomyopathy) 10/2019 - 03/2003
3	Hypoxia (Hypoxemia) 01/2018 - 01/2016
3	Vascular Diseases (Vascular Disease) 01/2017 - 05/2003
3	Congenital Heart Defects (Congenital Heart Defect) 01/2007 - 03/2006
2	Inflammation (Inflammations) 03/2024 - 07/2014
2	Hemorrhage 01/2024 - 01/2021
2	Stroke (Strokes) 01/2023 - 01/2020
2	Chronic Obstructive Pulmonary Disease (COPD) 11/2021 - 01/2021
2	Lung Diseases (Lung Disease) 01/2021 - 01/2019
2	Renal Insufficiency (Renal Failure) 01/2021 - 07/2010
2	Cough 01/2021 - 12/2011
2	COVID-19 11/2020 - 10/2020
2	Pericardial Effusion 03/2015 - 07/2010
2	Fibrosis (Cirrhosis) 07/2014 - 11/2012
2	Coronary Artery Disease (Coronary Atherosclerosis) 05/2007 - 01/2002
1	Genetic Predisposition to Disease (Genetic Predisposition) 03/2024
1	Aortic Valve Stenosis (Aortic Stenosis) 01/2023
1	Pre-Eclampsia (Preeclampsia) 06/2022
1	Thrombophilia 11/2021
1	Dyspepsia (Indigestion) 01/2021
1	Familial Primary Pulmonary Hypertension 01/2021
1	Obesity 01/2021
1	Osteoarthritis 01/2021
1	Pregnancy Complications 01/2021
1	Pulmonary Veno-Occlusive Disease (Veno Occlusive Disease, Pulmonary) 01/2021
1	Respiratory Tract Infections (Respiratory Tract Infection) 01/2021

Drug/Important Bio-Agent (IBA)

13	riociguatIBA 01/2024 - 02/2015
13	Epoprostenol (Prostacyclin)FDA LinkGeneric 07/2022 - 12/2005
13	treprostinil FDA Link 07/2022 - 12/2005
8	Bosentan (Tracleer)FDA Link 10/2020 - 04/2006
6	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 01/2021 - 03/2013
5	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2021 - 07/2010
4	Endothelins (Endothelin)IBA 07/2014 - 07/2008
3	selexipagIBA 12/2021 - 01/2019
3	Oxygen (Dioxygen)IBA 11/2021 - 01/2018
3	macitentanIBA 01/2021 - 07/2014
3	Phosphodiesterase 5 InhibitorsIBA 10/2020 - 03/2013
3	Sildenafil Citrate (Viagra)FDA Link 10/2020 - 07/2008
3	Biomarkers (Surrogate Marker)IBA 01/2018 - 09/2011
3	sitaxsentanIBA 12/2015 - 01/2007
3	Endothelin Receptor AntagonistsIBA 11/2012 - 04/2006
2	Guanosine Monophosphate (5' Guanylic Acid)IBA 01/2024 - 01/2017
2	Soluble Guanylyl CyclaseIBA 01/2024 - 04/2017
2	Plasminogen Activator Inhibitor 1IBA 01/2024 - 05/2003
2	ambrisentan FDA Link 12/2023 - 01/2021
2	Tadalafil (Cialis)FDA Link 12/2023 - 01/2021
2	pro-brain natriuretic peptide (1-76)IBA 01/2023 - 01/2021
2	omega-Chloroacetophenone (Mace)IBA 01/2023 - 01/2017
2	ProstaglandinsIBA 01/2022 - 12/2011
2	Iloprost (Ventavis)FDA Link 12/2021 - 02/2013
2	DiureticsIBA 11/2021 - 04/2004
2	7-(N-(3-aminopropyl)amino)heptan-2-oneIBA 01/2021 - 01/2021
2	ElectrolytesIBA 11/2020 - 04/2004
2	Vasodilator Agents (Vasodilators)IBA 10/2020 - 01/2013
2	Proteins (Proteins, Gene)FDA Link 01/2018 - 08/2011
2	Milrinone (Primacor)FDA LinkGeneric 08/2004 - 03/2003
1	SterolsIBA 03/2024
1	Bile Acids and Salts (Bile Acids)IBA 03/2024
1	OxysterolsIBA 03/2024
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2024
1	Valproic Acid (Depakote)FDA LinkGeneric 01/2024
1	Delayed-Action PreparationsIBA 01/2024
1	PowdersIBA 12/2022
1	Vardenafil Dihydrochloride (Levitra)FDA Link 12/2022
1	DNA (Deoxyribonucleic Acid)IBA 10/2022
1	PH.3IBA 06/2022
1	Blood Group Antigens (Blood Groups)IBA 11/2021
1	Phosphotransferases (Kinase)IBA 10/2021
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 10/2021
1	Macrophage Colony-Stimulating FactorIBA 10/2021
1	Proto-Oncogene Proteins c-kit (Proto-Oncogene Protein c-kit)IBA 10/2021
1	Oral ContraceptivesIBA 01/2021
1	Methamphetamine (Desoxyn)FDA LinkGeneric 01/2021
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2021
1	Illicit Drugs (Recreational Drugs)IBA 01/2021

Therapy/Procedure

40	Therapeutics 12/2023 - 01/2002
11	Heart-Assist Devices 11/2020 - 05/2002
5	Lung Transplantation 01/2019 - 09/2012
4	Heart Transplantation (Grafting, Heart) 05/2007 - 01/2002
3	Transplantation 01/2019 - 01/2004
2	Precision Medicine 12/2021 - 01/2017
2	Liver Transplantation 11/2012 - 05/2009
1	Transcatheter Aortic Valve Replacement 01/2023
1	Denervation 01/2023